Which drug affects the metabolism of omeprazole more? How do you know?

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Which drug affects the metabolism of omeprazole more? How do you know?

Fluconazole and ketoconazole are both reversible inhibitors of CYP2C19. When omeprazole was used as a victim drug, their Ki’s were reported as 2.9 and 4.7 mM, respectively. Estimate the AUCR for their interaction with omeprazole (fm=0.87) using Cmax values of fluconazole and ketoconazole of 29.4 and 1.87 mM, respectively. Also estimate AUCR using the unbound concentration of the inhibitors (fu values of fluconazole and ketoconazole are 0.89 and 0.01, respectively). Which drug affects the metabolism of omeprazole more? How do you know?

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