What fraction of the enzyme will have a bound substrate under the conditions described above?

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What fraction of the enzyme will have a bound substrate under the conditions described above?

A) Fluvastatin is a cholesterol lowering drug whose mechanism of action is the inhibition of HMG-CoA Show more A) Fluvastatin is a cholesterol lowering drug whose mechanism of action is the inhibition of HMG-CoA reductase. If a patient takes a 80.0 mg dose of fluvastatin what is the concentration of fluvastatin in the blood? Assume the patient has 5.0 L of blood. The molecular weight of fluvastatin is 411. (please answer in uM) B) Fluvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 3.0 10-4 ?M. What fraction of the enzyme will have a bound substrate under the conditions described above? Assume the concentration of HMG-CoA is 16 ?M and the KM for HMG-CoA reductase is 1.4 ?M. C)After a period of time all but 0.10% of the fluvastatin in the blood is metabolized. What fraction of the enzyme will have bound substrate under these conditions? PLEASE show all work so I can learn how to do this. Thank-you!!!! Show less

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