One can isolate rare mutations in the lac operator (lacO)

One can isolate rare mutations in the lac operator (lacO)

One can isolate rare mutations in the lac operator (lacO) gene that produce a non-inducible (super-repressed) phenotype. Like other lacO mutations, these mutations (called O^0 ) are cisdominant.
a) Propose a model for the molecular basis of O^0 mutations.
b) Based upon your model, explain why O^0 mutants are cis-dominant. (Consider the situation in O+ /O^0 and in O^c /O^0 .)
c) Based upon your model, make predictions about whether or not O^0 mutations are epistatic to lacI– (constitutive) mutations or to lacI+ (inducible).

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