. Explain the role of aldolase B in the metabolism of fructose including the products of the reaction.
More and more researchers are discovering that many diseases are caused by biochemical deficiencies or defects. That is instead of indicating that a disease is caused by a nutritional deficiency researchers recognize that an underlying cause may be a single molecular structure within a cell that fails to turn a cellular process on or off. This is particularly true regarding metabolism. For this task you will consider the biochemical implications in a metabolic disorder involving a normal component of foodfructose.Requirements:Assemble your work in a document (e.g. Microsoft Word Google Document etc.) (including diagrams text explanations and references) and ensure that written responses are prepared in a narrative style (complete sentences rather than bullet points). NOTE: Very brief explanations (such as bullet points) are more likely to result in originality concerns and delays in evaluation.Note: Please save submission documents as *.doc *.docx *rtf or *.pdf files. If you are using Google Documents you must save the file in *.pdf format and upload the *.pdf file.A. Demonstrate your understanding of the biochemical basis of hereditary fructose intolerance (HFI) by doing the following:1. Describe two important features that make all enzymes catalysts.2. Explain how enzymes act as protein catalysts in the first two steps of fructose metabolism in the liver.3. Discuss the specific substrate acted on by aldolase B during the metabolism of fructose including how the substrate is made.4. Explain the role of aldolase B in the metabolism of fructose including the products of the reaction.a. Identify the different pathways the products of aldolase B can enter.5. Discuss how a deficiency in aldolase B is responsible for HFI by doing the following:a. Explain how the amount of the substrate of aldolase B is impacted by the deficiency.b. Explain the role of the substrate in producing the symptoms of HFI.B. Explore how mitochondrial disease can occur at multiple levels in different mitochondrial processes by doing the following:1. Explain what would hypothetically happen to the amount of ATP available to a cell if the entire Cori cycle (glucose going to lactate and then back to glucose) were to occur and remain within that single cell (i.e. a muscle cell).a. Justify your response to part B1 by providing specific numbers of ATP generated or used in the different parts of the cycle.Note: This is a hypothetical defect so the explanation should not include descriptions of any known disease.a. Discuss what happens to the product of the enzyme from part B3 that includes each of the following points:whether the entire cycle will continue to functionwhat will happen to the cycle products and their contribution to ATP production4. Explain the specific role of coenzyme Q10 in the electron transport chain.a. Explain how coenzyme Q10 leads to ATP synthesis.i. Describe the electron transport chain and oxidative phosphorylation.C. When you use sources include all in-text citations and references in APA format.Note: When using sources to support ideas and elements in an assessment the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment.Note: No more than a combined total of 30% of a submission can be directly quoted or closely paraphrased from sources even if cited correctly. For tips on using APA style please refer to the APA Handout web link included in the General Instructions section
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