. Draw the structure of cGMP and compare it to Viagra

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. Draw the structure of cGMP and compare it to Viagra

Erectile Dysfunction (ED) is thought to affect 30 million men in the United States. Drugs which targ Show more Erectile Dysfunction (ED) is thought to affect 30 million men in the United States. Drugs which target this condition as associated with maintaining the cGMP-medi- ated signal transduction pathway leading to vasorelaxation in the smooth muscle of the penis. Humans and other primates control cGMP in this tissue by nitric oxide synthesized by nitric oxide synthase released from nerves in response to arousal or from endothelial cells. The NO passes directly into neighboring smooth muscle cells where it binds it soluable guanylyl cyclase receptor thus synthesizing cGMP. (See below) 5. Viagra (sidenafil) is an inhibitor of PDE5 (phosphodiesterase 5). PDE5 is a cGMP specific phosphodiesterase which breaks down cGMP into GMP. Draw the structure of cGMP and compare it to Viagra. What are the structural similarities and differences? Show less

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