Describe two specific types of pemphigus which demiglein is being attacked and why it has the specific features that it does.
#2 Pemphigus is a rare autoimmune disease that causes watery blisters to form all over the skin inc Show more #2 Pemphigus is a rare autoimmune disease that causes watery blisters to form all over the skin including and especially the mucous membranes of the mouth and nose. These blisters are extremely itchy and easily pop or fall off developing into deep sores that are prone to nasty infections. It was found that pemphigus is caused by the production of autoantibodies to a family of proteins called desmogleins which is within the superfamily of proteins known as cadherins. A.) What are cadherins and what structures do they help form? B.) What cellular structures specifically have the desmoglein proteins and where are these found in the human body? C.) Explain the symptoms of pemphigus given the underlying cause. D.) It turns out that pemphigus is actually a family of related conditions with each version of the disease caused by autoimmune attack against a different member of the desmoglein family. Describe two specific types of pemphigus which demiglein is being attacked and why it has the specific features that it does. #3 Recently a possible explanation has been found for a strange kidney syndrome called Renal Magnesium Wasting: a mutation in the gene for claudin-16 or claudin-19. A.) What are the symptoms of renal magnesium wasting? B.) Where in the body are these two genes expressed? C.) Assuming the mutations in the claudin genes impair their function (rather than enhancing function) how would this explain the symptoms of the disease? Show less
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