Describe the approaches that may be used to control for this variability. (maximum 250 words tota Intra-Individual Variability Essay During the pre-clinical development of a new anti-cancer drug it is determined that the drug is requires
Phamacology Systemic Clearance Extended Calculation A drug has the following pharmacokinetic parameters: Fraction unbound (fu): 0.5 Clearance by active secretion (CLsec): 2L/hr Fraction reabsorbed (FR): 0.25 Hepatic Extraction Ratio (EH): 0.25 Question: Calculate the total SYSTEMIC CLEARANCE for this drug showing all working out, and stating all assumptions: Therapeutic Monitoring Essay A number of factors can contribute to inter- and intra- individual variability in the pharmacokinetics of a drug, and because of this it is sometimes necessary to use a different dose of the same drug to treat different people. Question: (a) Identify the circumstances and populations where variability may be most important. (b) Describe the approaches that may be used to control for this variability. (maximum 250 words tota Intra-Individual Variability Essay During the pre-clinical development of a new anti-cancer drug it is determined that the drug is requires hepatic activation in order to elicit a therapeutic effect. Further studies identify CYP2C19 as the sole enzyme involved in the activation of this drug. Question: Select ONE specific factor (from the categories environmental, genetic or physiological) that may contribute to intra-individual variability in the activation of THIS drug, and describe the potential consequences of this variability in terms of patient response and tolerability. (maximum 250 words
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