Case 5 DHS 652
Please answer the following questions in a paper of at least 6 pages:
A researcher is studying the effect of factors that may contribute to a birth defect. The following is a table summarizing the results of bivariate and multivariate analysis.
Table 1. Bivariate versus Multivariate
Variable
Crude OR
95% CI
Adjusted OR
95% CI
Gene X
0.986
0.974–0.998
0.985
0.971–0.999
Gene Y
4.317
1.916–9.727
3.430
1.377–8.547
Gene Z
2.02
1.081–3.891
1.34
0.854–2.115
Gene T
3.365
1.021–11.088
6.236
1.562–24.892
Identify variables from Table 1 that should be further analyzed (to rule out whether they are confounders or effect modifiers). Briefly provide rationale.
Stratified analysis was conducted on one of the genes in Table 1 and odds ratios were obtained. What do these results suggest:
Drug A=0: OR=2.2 for birth defect given presence of gene
Drug A=1: OR=1.4 for birth defect given presence of gene
Critically review the following controversial paper published (and later retracted) by Wakefield et al, which implicated MMR vaccine as a possible etiologic contributor to Autism, etc. You may use either version for your review. Describe potential sources of bias and other limitations in the study:
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children A J Wakefield, S H Murch, A Anthony, J Linnell, D M Casson, M Malik, M Berelowitz, A P Dhillon, M A Thomson, P Harvey, A Valentine, S E Davies, J A Walker-Smith The Lancet, Volume 351, Number 9103 28 February 1998
Pro 7 Con Arguments: “Should any vaccines be required for children? Retrieved from http://vaccines.procon.org/ on November 5, 2013. The post Case 5 DHS 652 first appeared on cipdpro.co.uk .Case 5 DHS 652 was first posted on December 6, 2023 at 11:22 am.©2019 "cipdpro.co.uk ". Use of this feed is for personal non-commercial use only. If you are not reading this article in your feed reader, then the site is guilty of copyright infringement. Please contact me at admin@cipdpro.co.uk
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