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(3 points) The following hypothetical lead competmd contains

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12. (3 points) The following hypothetical lead competmd contains an ester derivative that is thought to bindto a hydrophobic pocket within an enzyme active site. You hypothesize that the ester group is too small,and is not ﬁlling the entire hydrophobic pocket. Draw a reaction scheme (show arrows and reagents) thatwill lead to a new compound with an alternative ester derivative containing a larger hydrophobicfunctional group. 0M90Y0 O0M9

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(3 points) The following hypothetical lead competmd contains

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