Eukaryotic chromosome.
I need the following discussion questions in about 200 words each. Please provide each question with its own references.
DQ 1
You have studied the essential structural elements of a functional eukaryotic chromosome. Select an essential structural element of interest. What are the implications of this element for research, health, and life span? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DQ 2
Identify a specific disease encountered in your clinical practice or personal life. Can your patient’s understanding of DNA/RNA replication, transcription, and translation affect the management of the disease? Explain. Support your rationale with a minimum of two scholarly sources.
RESOURCES
Li, D., Xia, H., Li, Z., Hua, L., & Li, L. (2015). Identification of novel breast cancer subtype-specific biomarkers by integrating genomics analysis of DNA copy number aberrations and miRNA-mRNA dual expression profiling. BioMed Research International, 2015, 1-17. https://doi.org/10.1155/2015/746970
Calzone, K. A., Kirk, M., Tonkin, E., Badzek, L., Benjamin, C., & Middleton, A. (2018). The global landscape of nursing and genomics. Journal of Nursing Scholarship, 50(3), 249-256. https://doi.org/10.1111/jnu.12380
Pellestor, F. (2019). Chromoanagenesis: Cataclysms behind complex chromosomal rearrangements. Molecular Cytogenetics, 12(6). https://doi.org/10.1186/s13039-019-0415-7
My Family Health Portrait– http://kahuna.clayton.edu/jqu/FHH/html/index.html
MODULE 2
DQ 1
Identify a complex inheritance health issue you encountered in your clinical practice or personal life. How would you approach working with a patient of a complex inheritance health issue? Explain. Support your rationale with a minimum of two scholarly sources.
DQ 2
Refer to the complex inheritance health issue identified in DQ 1. Given available genetic tests, which would you use to screen and diagnose this issue? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
RESOURCES
Rosenbaum, P. (2017). The yin and yang of clinical research. Developmental Medicine and Child Neurology, 59(12), 1208. https://onlinelibrary.wiley.com/doi/full/10.1111/dmcn.13553
Hussain, S., Moiz, B., Aqeel, S., & Zaidi, N. (2017). Issues in reproductive health in females having inherited bleeding disorders in Pakistan. Haemophilia, 23(4), 367-370. https://doi.org/10.1111/hae.13254
MODULE 3
DQ 1
A multigenerational family health history can facilitate the management of a patient’s disease. What model would you use to create a multigenerational family health history for a patient? Explain. Support your rationale with a minimum of two scholarly sources.
DQ 2
Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
RESOURCES
Goergen, A. F., Ashida, S., Skapinsky, K., de Heer, H. D., Wilkinson, A. V., & Koehly, L. M. (2016). What you don’t know: Improving family health history knowledge among multigenerational families of Mexican origin. Public Health Genomics, 19(2), 93-101. https://doi.org/10.1159/000443473
Welch, B. M., Wiley, K., Pflieger, L., Achiangia, R., Baker, K., Hughes-Halbert, C., Morrison, H., Schiffman, J., & Doerr, M. (2018). Review and comparison of electronic patient-facing family health history tools. Journal of Genetic Counseling, 27(2), 381-391. https://doi.org/10.1007/s10897-018-0235-7
Canary, H. E., Elrick, A., Pokharel, M., Clayton, M., Champine, M., Sukovic, M., Jung, H. S., & Kaphingst, K. A. (2019). Family health history tools as communication resources: Perspectives from Caucasian, Hispanic, and Pacific Islander families. Journal of Family Communication, 19(2), 126-143. https://doi.org/10.1080/15267431.2019.1580195
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